The test remains very much a "work in progress", the researchers, from Oxford University, say, but could increase the number of cancers identified.
Often, patients have symptoms, such as weight loss, with a range of possible causes and require multiple tests and hospital visits.
More than 350 of those in the study - the biggest of its kind in patients with suspected cancer symptoms - were subsequently diagnosed with cancer, using traditional methods such as scans and biopsies. About:
A blood test for more than 50 types of cancer has shown real promise in a major NHS trial, researchers say.
The test correctly revealed two out of every three cancers among 5,000 people who had visited their GP with suspected symptoms, in England or Wales.
In 85% of those positive cases, it also pinpointed the original site of cancer.
UFABET The Galleri test looks for distinct changes in bits of genetic code that leak from different cancers. Spotting treatable cancer early can save lives.
75% of those testing positive on the blood test were found to have cancer
2.5% of those testing negative were found to have cancer
Although not accurate enough to "rule in or rule out cancer", the test was really useful for patients lead researcher Prof Mark Middleton told BBC News.
"The test was 85% accurate in detecting the source of the cancer - and that can be really helpful because so many times it is not immediately obvious when you have got the patient in front of you what test is needed to see whether their symptoms are down to cancer," he said.
"With that prediction from the test, we can decide whether to order a scope or a scan and make sure we are giving the right test the first time."
The findings will be presented at the American Society of Clinical Oncology conference, in Chicago.
